To meet the challenges of antibiotic resistance and specter of a post-antibiotic era, the Carlson lab is pursuing the discovery of the master regulators of bacterial growth and communication and ultimately, the identification of new antibiotics through the application of diverse tools at the interface of chemistry and biology. We are currently pursuing four intersecting objectives: 1) Pursuit of the generation of chemical probes and inhibitors for the global profiling and inhibition of histidine kinases, a ubiquitous class of proteins essential for signal transduction in bacteria, 2) To deepen our understanding of the multi-protein systems that dictate bacterial growth and division, we are designing selective probes for imaging and proteomics with specific focus on the penicillin-binding proteins, 3) Development of novel methods to explore the association between bacteria and their biomolecules with nanoparticles, and 4) Generation of powerful strategies to explore and interpret the molecular language used by bacteria to respond to environmental cues using a combination of mass spectrometry, informatics, and novel separation reagents.
Each of our research objectives is independently important for potential therapeutic development. However, it is our focus on the synergy between multiple areas that is the foundation for our unique ability to detect, interrupt and exploit the master regulators of bacterial behavior.
Carlson Lab Mission Statement
We believe that collaboration among people of all cultures, experiences and backgrounds enhances science and contributes to excellence in teaching, learning, and research. We strive to promote a climate that celebrates our differences and strengthens our group and the scientific community by embracing and working to increase diversity, equity, and inclusion. Learn more about the efforts of our department and Professor Carlson to promote a welcoming and safe environment to learn and perform research.