The Carlson research group is highly multidisciplinary and members gain expertise in many areas including organic synthesis, mass spectrometry, probe and inhibitor design, chemical proteomics, metabolomics, microbiology, biochemistry, imaging and molecular and cellular biology.
The Carlson lab is pursuing discovery of the master regulators of bacterial growth and communication and utilizing the tools of both chemistry and biology to address the critical challenge of antibiotic discovery. We have four intersecting research objectives: 1) Generation of chemical probes and inhibitors for the global profiling and inhibition of histidine kinases, a ubiquitous class of proteins essential for signal transduction in bacteria, 2) Understanding the multi-protein systems that dictate bacterial growth and division through the design of selective probes for imaging and proteomics, with focus on the penicillin-binding proteins, 3) Development of novel methods to explore the association between bacteria and their biomolecules with nanoparticles, and 4) Generation of powerful strategies to explore and interpret the molecular language used by bacteria to respond to environmental cues.
Each of our research objectives is independently important for potential therapeutic development. However, it is our focus on the synergy between multiple areas that is the foundation for our unique ability to detect, interrupt and exploit the master regulators of bacterial behavior.
Carlson Lab Mission Statement
We believe that collaboration among people of all cultures, experiences, and backgrounds enhances science and contributes to excellence in teaching, learning, and research. We strive to promote a climate that celebrates our differences, dismantle racist and other discriminatory practices, and promote an environment where all have the opportunity to thrive. Learn more about the efforts of our department and Professor Carlson in a recent eNews article and on the committee website to promote a welcoming and safe environment to learn and perform research.