Bacterial Signal Transduction and Antivirulence Agents

Two-component systems are essential proteins for bacterial response to their local environment. This includes histidine kinases (HKs), for which we have developed numerous activity-based probes and inhibitors.

Recent Papers:

88. Evaluating the Link Between Efflux Pump Expression and Motility Phenotypes in Pseudomonas aeruginosa Treated with Virulence Inhibitors

Lembke, H.K; Nauta, K.M.; Hunter, R.C.; Carlson, E. E. ACS Infect. Dis. 2025, 11, 2080–2089.

https://doi.org/10.1021/acsinfecdis.5c00053

Targeting multidrug resistant Staphylococcus infections with bacterial histidine kinase inhibitors

Espinasse, A.,† Goswami, M.,† Yang, J., Vorasin, O., Ji, Y.* and Carlson, E. E.* Chem Sci, 2023, 14, 5028-5037.

† Co-first authors

https://doi.org/10.1039/D2SC05369A

Full Publication List

What types of methods will you learn/use on this project?

Organic synthesis, chemical proteomics and mass spectrometry, medicinal chemistry, molecular modeling, protein expression/purification, microbiology, and molecular biology.