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Two-component systems are essential proteins for bacterial response to their local environment. This includes histidine kinases (HKs), for which we have developed numerous activity-based probes and inhibitors.
Recent Papers:
Recent Papers:
Targeting multidrug resistant Staphylococcus infections with bacterial histidine kinase inhibitors
Espinasse, A.,† Goswami, M.,† Yang, J., Vorasin, O., Ji, Y.* and Carlson, E. E.* Chem Sci, 2023, 14, 5028-5037.
† Co-first authors
Cationic Polymers Enable Internalization of Negatively Charged Chemical Probe into Bacteria
Lembke, H. K.,† Espinasse, A.,† Hanson, M. G., Grimme, C. J., Tan, Z., Reinke, T. M. and Carlson, E. E. ACS Chem. Biol., 2023, 18, 2063–2072.
† Co-first authors
What types of methods will you learn/use on this project?
Organic synthesis, chemical proteomics and mass spectrometry, medicinal chemistry, molecular modeling, protein expression/purification, microbiology, and molecular biology.
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