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Two-component systems are essential proteins for bacterial response to their local environment. This includes histidine kinases (HKs), for which we have developed numerous activity-based probes and inhibitors.
Recent Papers:
Recent Papers:
88. Evaluating the Link Between Efflux Pump Expression and Motility Phenotypes in Pseudomonas aeruginosa Treated with Virulence Inhibitors
Lembke, H.K; Nauta, K.M.; Hunter, R.C.; Carlson, E. E. ACS Infect. Dis. 2025, 11, 2080–2089.
Targeting multidrug resistant Staphylococcus infections with bacterial histidine kinase inhibitors
Espinasse, A.,† Goswami, M.,† Yang, J., Vorasin, O., Ji, Y.* and Carlson, E. E.* Chem Sci, 2023, 14, 5028-5037.
† Co-first authors
What types of methods will you learn/use on this project?
Organic synthesis, chemical proteomics and mass spectrometry, medicinal chemistry, molecular modeling, protein expression/purification, microbiology, and molecular biology.
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