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Penicillin-binding proteins are required for bacterial growth and division. Most organisms possess many different PBPs but it is not well understood why this is advantageous for bacteria. We have developed numerous activity-based probes and inhibitors for the PBPs.
Recent Papers:
Recent Papers:
Mitchell, S. M., Kearns, D. B. and Carlson, E. E. bioRxiv, 2023, 533529v1. Appl. Environ. Microbiol., 2024, 90, e0054823.
https://doi.org/10.1128/aem.00548-23
Shirley, J.D.;† Gillingham, J.R.;† Nauta, K.M.;† Diwakar, S.; Carlson, E. E. ACS Infect. Dis. 2024, 10, 4137-4145.
† Co-first authors
https://doi.org/10.1021/acsinfecdis.4c00370
What types of methods will you learn/use on this project?
What types of methods will you learn/use on this project?
Chemical biology, organic synthesis, chemical proteomics and mass spectrometry, fluorescence microscopy, bacterial physiology, molecular modeling, and biochemistry.
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